Validating the genomic signature of pediatric septic shock western men dating chinese women
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Septic shock heterogeneity has important implications for clinical trial implementation and patient management. Using computer-based image analysis, patients were classified into 1 of 3 subclasses (“A”, “B”, or “C”) based on color and pattern similarity relative to reference mosaics generated from the original derivation cohort.
Subclass A patients had higher illness severity relative to subclasses B and C as measured by maximal organ failure, fewer intensive care unit-free days, and a higher Pediatric Risk of Mortality score. A major challenge in critical care medicine is the development of clinically feasible stratification strategies to manage this heterogeneity for the design of more effective clinical trials and individualized patient management [3, 4].
Patients in subclass A were characterized by repression of genes corresponding to adaptive immunity and glucocorticoid receptor signaling. We are addressing the challenge of septic shock heterogeneity by leveraging the discovery potential of whole-genome expression profiling .
Search for validating the genomic signature of pediatric septic shock:
Statistical comparison of the three putative subclasses (analysis of variance, Bonferonni correction, While septic shock is fundamentally an infection-based disease entity, it is not a singular, homogenous disease in the traditional sense.